Issue 45, 2021

A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

Abstract

Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.

Graphical abstract: A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

Supplementary files

Article information

Article type
Communication
Submitted
05 6月 2021
Accepted
27 9月 2021
First published
28 9月 2021

Nanoscale, 2021,13, 18941-18946

A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

S. Uchida, Y. Yamaberi, M. Tanaka and M. Oba, Nanoscale, 2021, 13, 18941 DOI: 10.1039/D1NR03600A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements