Issue 13, 2021

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

Abstract

Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.

Graphical abstract: Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

Supplementary files

Article information

Article type
Communication
Submitted
16 12月 2020
Accepted
19 2月 2021
First published
20 2月 2021

Nanoscale, 2021,13, 6394-6399

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

W. Zhao, H. Wang, H. Wang, Y. Han, Z. Zheng, X. Liu, B. Feng and H. Zhang, Nanoscale, 2021, 13, 6394 DOI: 10.1039/D0NR08887K

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