Issue 22, 2021

An amino acid-based supramolecular nanozyme by coordination self-assembly for cascade catalysis and enhanced chemodynamic therapy towards biomedical applications

Abstract

The clinical translation of chemodynamic therapy has been highly obstructed by the insufficient intracellular H2O2 level in diseased tissues. Herein, we developed a supramolecular nanozyme through a facile one-step cooperative coordination self-assembly of an amphipathic amino acid and glucose oxidase (GOx) in the presence of Fe2+. The results demonstrated that the supramolecular nanozyme possessed cascade enzymatic activity (i.e., GOx and peroxidase), which could amplify the killing efficacy of hydroxyl radicals (˙OH) via self-supplying H2O2, finally achieving synergistic starvation–chemodynamic cancer therapy in vitro. Additionally, this cascade nanozyme also exhibited highly effective antibacterial activity on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) without the need for additional H2O2. This work provided a promising strategy for the design and development of nanozymes for future biomedical applications.

Graphical abstract: An amino acid-based supramolecular nanozyme by coordination self-assembly for cascade catalysis and enhanced chemodynamic therapy towards biomedical applications

Supplementary files

Article information

Article type
Paper
Submitted
11 8月 2021
Accepted
11 9月 2021
First published
16 9月 2021
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2021,3, 6482-6489

An amino acid-based supramolecular nanozyme by coordination self-assembly for cascade catalysis and enhanced chemodynamic therapy towards biomedical applications

E. Song, Y. Li, L. Chen, X. Lan, C. Hou, C. Liu and C. Liu, Nanoscale Adv., 2021, 3, 6482 DOI: 10.1039/D1NA00619C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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