Issue 39, 2021

Determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography: a review

Abstract

Malaria is a life-threatening disease being treated by oral medication. This is the best treatment to reduce morbidity and mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials. According to the World Health Organization, the most common antimalarial drugs are chloroquine, primaquine, mefloquine, lumefantrine, artemether, and artesunate in single dosage forms or fixed-dose combination. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to the determination of these antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography in the last 10 years, along with statistical analyses of the methods.

Graphical abstract: Determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography: a review

Article information

Article type
Critical Review
Submitted
09 7月 2021
Accepted
09 9月 2021
First published
09 9月 2021

Anal. Methods, 2021,13, 4557-4584

Determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography: a review

E. A. Penna, J. C. Q. de Souza, M. A. L. de Oliveira and P. R. Chellini, Anal. Methods, 2021, 13, 4557 DOI: 10.1039/D1AY01173A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements