Issue 29, 2020

Synthesis of azetidines by aza Paternò–Büchi reactions

Abstract

The [2 + 2] photocycloaddition reaction between an imine and an alkene component, the aza Paternò–Büchi reaction, is one of the most efficient ways to synthesize functionalized azetidines. However, the application of the aza Paternò–Büchi reaction has been met with limited success due to the inherent challenges associated with this approach. This review covers the current scope and limitations of reported examples of aza Paternò–Büchi reactions in organic synthesis. An outlook is provided, which highlights recent improvements and the discovery of new reaction protocols that have overcome some long-standing challenges within this field of research.

Graphical abstract: Synthesis of azetidines by aza Paternò–Büchi reactions

Article information

Article type
Minireview
Submitted
20 2月 2020
Accepted
06 5月 2020
First published
12 6月 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 7553-7561

Synthesis of azetidines by aza Paternò–Büchi reactions

A. D. Richardson, M. R. Becker and C. S. Schindler, Chem. Sci., 2020, 11, 7553 DOI: 10.1039/D0SC01017K

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