Issue 30, 2020

Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

Abstract

A simple two catalyst component system consisting of primary β-amino alcohols as a catalyst and amino acids as a co-catalyst put together works as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones to afford the chiral spirooxindole–tetrahydropyranones in good chemical yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee).

Graphical abstract: Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

Supplementary files

Article information

Article type
Paper
Submitted
03 4月 2020
Accepted
30 4月 2020
First published
05 5月 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 17486-17491

Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

P. Parasuraman, Z. Begum, M. Chennapuram, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M. Takeshita and H. Nakano, RSC Adv., 2020, 10, 17486 DOI: 10.1039/D0RA03006F

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