Issue 18, 2020

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Graphical abstract: Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Supplementary files

Article information

Article type
Paper
Submitted
05 2月 2020
Accepted
08 4月 2020
First published
30 4月 2020
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2020,18, 3607-3612

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

H. L. Parker, R. M. F. Tomás, C. M. Furze, C. S. Guy and E. Fullam, Org. Biomol. Chem., 2020, 18, 3607 DOI: 10.1039/D0OB00253D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements