Issue 6, 2020

Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

Abstract

This review highlights the different enantioselective catalyst-controlled cascades creating multiple alcohol functions through the formation of several carbon–carbon bonds. Through subsequent simple derivatization, these strategies ensure the rapid preparation of 1,3-polyols. Thanks to the use of efficient metal- or organo-catalysts, these cascades enable the selective assembly of multiple substrates considerably limiting operations and waste generation. For this purpose, several mono- or bi-directional approaches have been devised allowing successive C–C bond-forming events. The considerable synthetic economies these cascades enable have been demonstrated in the preparation of a wide variety of complex bioactive natural products, notably polyketides.

Graphical abstract: Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

Article information

Article type
Review Article
Submitted
17 12月 2019
Accepted
13 1月 2020
First published
14 1月 2020
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2020,18, 1025-1035

Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

C. Sperandio, J. Rodriguez and A. Quintard, Org. Biomol. Chem., 2020, 18, 1025 DOI: 10.1039/C9OB02675D

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