Issue 6, 2020

Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

Abstract

The increase in antibiotic resistance reported worldwide poses an immediate threat to human health and highlights the need to find novel approaches to inhibit bacterial growth. In this study, we present a series of gold nanoparticles (Au NPs) capped by different N-heterocyclic molecules (N_Au NPs) which can serve as broad-spectrum antibacterial agents. Neither the Au NPs nor N-heterocyclic molecules were toxic to mammalian cells. These N_Au NPs can attach to the surface of bacteria and destroy the bacterial cell wall to induce cell death. Sonochemistry was used to coat Au NPs on the surface of fabrics, which showed superb antimicrobial activity against multi-drug resistant (MDR) bacteria as well as excellent efficacy in inhibiting bacterial biofilms produced by MDR bacteria. Our study provides a novel strategy for preventing the formation of MDR bacterial biofilms in a straightforward, low-cost, and efficient way, which holds promise for broad clinical applications.

Graphical abstract: Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

Supplementary files

Article information

Article type
Communication
Submitted
03 3月 2020
Accepted
27 4月 2020
First published
28 4月 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 2293-2302

Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

L. Wang, M. Natan, W. Zheng, W. Zheng, S. Liu, G. Jacobi, I. Perelshtein, A. Gedanken, E. Banin and X. Jiang, Nanoscale Adv., 2020, 2, 2293 DOI: 10.1039/D0NA00179A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements