Issue 16, 2019

Recent developments in decarboxylative cross-coupling reactions between carboxylic acids and N–H compounds

Abstract

Carboxylic acids and their derivatives are ubiquitous compounds in organic chemistry, and are widely commercially available in a large structural variety. Recently, carboxylic acids have been frequently used as non-toxic and environmentally benign alternatives to traditional organohalide coupling partners in various carbon–carbon and carbon–heteroatom cross-coupling reactions. Along this line, several methods have been reported for the synthesis of nitrogen-containing organic compounds through decarboxylative cross-coupling reactions between carboxylic acids and N–H compounds. This review focuses on recent advances and discoveries on these reactions with special attention on the mechanistic aspects of the reactions.

Graphical abstract: Recent developments in decarboxylative cross-coupling reactions between carboxylic acids and N–H compounds

Article information

Article type
Review Article
Submitted
03 2月 2019
Accepted
04 3月 2019
First published
18 3月 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 8964-8976

Recent developments in decarboxylative cross-coupling reactions between carboxylic acids and N–H compounds

S. Arshadi, S. Ebrahimiasl, A. Hosseinian, A. Monfared and E. Vessally, RSC Adv., 2019, 9, 8964 DOI: 10.1039/C9RA00929A

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