Issue 42, 2019

Plant-derived chlorophyll derivative loaded liposomes for tri-model imaging guided photodynamic therapy

Abstract

Plant-derived chlorophyll derivatives with a porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to their poor water solubility, chlorophyll derivatives are very difficult to use in biomedical applications. In this work, pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles, a liposome-encapsulated chlorophyll derivative, are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer. The obtained liposome/PPa nanoparticles significantly enhance the water solubility of PPa, prolong blood circulation and optimize the bio-distribution in mice after intravenous injection. Utilizing their intrinsic fluorescence, high near-infrared (NIR) absorbance and extra radiolabeling, liposome/PPa nanoparticles could be used as excellent contrast agents for multimodal imaging including fluorescence (FL) imaging, photoacoustic (PA) imaging and SPECT/CT imaging. Under 690 nm laser irradiation at a low power density, liposome/PPa nanoparticles significantly inhibit tumor growth, further demonstrating the therapeutic efficiency of PDT using PPa. Therefore, our work developed liposome/PPa nanoparticles as multifunctional nanoagents for multimodal imaging guided PDT of cancer. This will further prompt the clinical applications of PPa in the future.

Graphical abstract: Plant-derived chlorophyll derivative loaded liposomes for tri-model imaging guided photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
12 8月 2019
Accepted
08 10月 2019
First published
10 10月 2019

Nanoscale, 2019,11, 19823-19831

Plant-derived chlorophyll derivative loaded liposomes for tri-model imaging guided photodynamic therapy

H. Zhou, L. Xia, J. Zhong, S. Xiong, X. Yi, L. Chen, R. Zhu, Q. Shi and K. Yang, Nanoscale, 2019, 11, 19823 DOI: 10.1039/C9NR06941K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements