Issue 15, 2019

Sensitivity enhancement in lateral flow assays: a systems perspective

Abstract

Lateral flow assays (LFAs) are rapid, inexpensive, easy-to-manufacture and -use tests widely employed in medical and environmental applications, particularly in low resource settings. Historically, LFAs have been stigmatized as having limited sensitivity. However, as their global usage expands, extensive research has demonstrated that it is possible to substantially improve LFA sensitivity without sacrificing their advantages. In this critical review, we have compiled state-of-the-art approaches to LFA sensitivity enhancement. Moreover, we have organized and evaluated these approaches from a system-level perspective, as we have observed that the advantages and disadvantages of each approach have arisen from the integrated and tightly interconnected chemical, physical, and optical properties of LFAs.

Graphical abstract: Sensitivity enhancement in lateral flow assays: a systems perspective

Article information

Article type
Critical Review
Submitted
30 1月 2019
Accepted
26 4月 2019
First published
28 6月 2019
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2019,19, 2486-2499

Sensitivity enhancement in lateral flow assays: a systems perspective

J. D. Bishop, H. V. Hsieh, D. J. Gasperino and B. H. Weigl, Lab Chip, 2019, 19, 2486 DOI: 10.1039/C9LC00104B

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