Issue 80, 2019

Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

Abstract

The pyrrolidine ring is a privileged structural motif in synthetic and medicinal chemisty. This review aims to highlight the high versatility of the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides for access to different types of stereochemical patterns in enantioselective pyrrolidine synthesis. Special attention will be paid to stereodivergent procedures giving rise to different stereoisomers from the same starting materials.

Graphical abstract: Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

Article information

Article type
Feature Article
Submitted
08 7月 2019
Accepted
13 9月 2019
First published
13 9月 2019

Chem. Commun., 2019,55, 11979-11991

Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

J. Adrio and J. C. Carretero, Chem. Commun., 2019, 55, 11979 DOI: 10.1039/C9CC05238K

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