Issue 27, 2018

Reversibly tuning hydrogel stiffness through photocontrolled dynamic covalent crosslinks

Abstract

Controlling the physical properties of soft materials with external stimuli enables researchers to mimic and study dynamic systems. Of particular interest are hydrogels, polymer networks swollen by water with broad applicability to biomedicine. To control hydrogel mechanics with light, researchers have relied on a limited number of photochemical reactions. Here we introduce an approach to reversibly tune hydrogel mechanics with light by manipulating the stability of dynamic covalent crosslinks at the molecular level. The equilibrium between a boronic acid and diol to form a boronic ester can be altered by the configuration of an adjacent azobenzene photoswitch. By irradiating branched polymers bearing azobenzene-boronic acid and diol end groups with two different wavelengths of light, we can stiffen or soften the resulting hydrogel. Alternating irradiation induces reversible mechanical changes. Rheological characterization reveals that the hydrogels are viscoelastic, exhibiting stress relaxation on the order of seconds, and the stiffness is tuned independently of the crossover frequency. We have also demonstrated that this approach can be extended to use visible light for both softening and stiffening. These photocontrolled dynamic covalent crosslinks provide a versatile platform for tunable dynamic materials.

Graphical abstract: Reversibly tuning hydrogel stiffness through photocontrolled dynamic covalent crosslinks

Supplementary files

Article information

Article type
Edge Article
Submitted
10 5月 2018
Accepted
15 6月 2018
First published
19 6月 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 5987-5993

Reversibly tuning hydrogel stiffness through photocontrolled dynamic covalent crosslinks

Joseph V. Accardo and J. A. Kalow, Chem. Sci., 2018, 9, 5987 DOI: 10.1039/C8SC02093K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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