Issue 1, 2018

Enantioselective synthesis of (−)-phaseic acid

Abstract

Phaseic acid (PA) has long been considered an inactive oxidation catabolite of the essential plant hormone abscisic acid (ABA). However, a recent study disclosed that PA actually acts as an ABA receptor agonist and is capable of prolonging ABA effects in vivo. Here, we report a simple, enantioselective synthesis of (−)-phaseic acid. Key transformations of our strategy include a facile hydrozirconation reaction and a critical, Mn(III)-catalyzed allylic oxidation.

Graphical abstract: Enantioselective synthesis of (−)-phaseic acid

Supplementary files

Article information

Article type
Research Article
Submitted
28 7月 2017
Accepted
17 9月 2017
First published
18 9月 2017

Org. Chem. Front., 2018,5, 29-31

Enantioselective synthesis of (−)-phaseic acid

W. Tu, C. Ning and J. Xu, Org. Chem. Front., 2018, 5, 29 DOI: 10.1039/C7QO00653E

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