Issue 77, 2017

Development of a metal-free amine oxidation method utilizing DEAD chemistry

Abstract

Herein, we examine the oxidative abilities of azodicarboxylates for the conversion of amines to imines. This method provides access to synthetically useful imine intermediates including β-carbolines, quinazolines and N-heterocyclic carbene precursors. The ability to recover spent azodicarboxylate for regeneration and further use underscores the applicability and appeal of this protocol.

Graphical abstract: Development of a metal-free amine oxidation method utilizing DEAD chemistry

Supplementary files

Article information

Article type
Paper
Submitted
18 8月 2017
Accepted
04 10月 2017
First published
17 10月 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 48848-48852

Development of a metal-free amine oxidation method utilizing DEAD chemistry

G. Wang, G. Piva de Silva, N. E. Wiebe, G. M. Fehr and R. L. Davis, RSC Adv., 2017, 7, 48848 DOI: 10.1039/C7RA09165F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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