Issue 10, 2017

Catalytic asymmetric synthesis of hetero-substituted oxindoles

Abstract

Chiral disubstituted oxindoles represent an important family of bioactive molecules. The construction of asymmetric quaternary carbon in the cyclopentane ring is therefore a challenging problem for organic chemists. In the last few years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds and the literature on spirocyclic derivatives, 3-substituted-3-hydroxyoxindoles and 3-substituted-3-aminooxindoles has been largely reviewed. The literature on other hetero-substituted oxindoles has not been fully reviewed after 2011. This review aims to fill this gap by covering the literature on these topics until the end of 2016. A special section is also devoted to indoline-thiones.

Graphical abstract: Catalytic asymmetric synthesis of hetero-substituted oxindoles

Article information

Article type
Review Article
Submitted
05 6月 2017
Accepted
04 7月 2017
First published
05 7月 2017

Org. Chem. Front., 2017,4, 2063-2078

Catalytic asymmetric synthesis of hetero-substituted oxindoles

R. Dalpozzo, Org. Chem. Front., 2017, 4, 2063 DOI: 10.1039/C7QO00446J

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