Issue 8, 2013

Synthetically defined glycoprotein vaccines: current status and future directions

Abstract

Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

Graphical abstract: Synthetically defined glycoprotein vaccines: current status and future directions

Article information

Article type
Perspective
Submitted
30 3月 2013
Accepted
03 5月 2013
First published
07 5月 2013
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2013,4, 2995-3008

Synthetically defined glycoprotein vaccines: current status and future directions

R. Adamo, A. Nilo, B. Castagner, O. Boutureira, F. Berti and G. J. L. Bernardes, Chem. Sci., 2013, 4, 2995 DOI: 10.1039/C3SC50862E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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