Issue 25, 2011

Hydrogen bond assisted activation of a dinitrile towards nucleophilic attack

Abstract

The possibility of tunable regioselective activation of a dinitrile towards nucleophilic attack was demonstrated. For that, a sulfo-arylhydrazone unit was introduced into malononitrile and the thus formed intramolecular hydrogen bond systems assisted specific nucleophilic attacks to the cyano moieties leading to a variety of amidines, carboxamides and iminoesters depending on the nucleophiles and conditions used.

Graphical abstract: Hydrogen bond assisted activation of a dinitrile towards nucleophilic attack

Supplementary files

Article information

Article type
Communication
Submitted
24 3月 2011
Accepted
04 5月 2011
First published
23 5月 2011

Chem. Commun., 2011,47, 7248-7250

Hydrogen bond assisted activation of a dinitrile towards nucleophilic attack

M. N. Kopylovich, K. T. Mahmudov, A. Mizar and A. J. L. Pombeiro, Chem. Commun., 2011, 47, 7248 DOI: 10.1039/C1CC11696G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements