Issue 31, 2022

A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

Abstract

Herein we report our study on the development of a catalytic one-pot process, showing the challenges and advantages encountered all over the way. At the end, we developed a regioselective, environmentally friendly, and operationally simple method to explore the reactivity of functionalized propargylic alkynes through three copper-catalysed reactions in a single reaction vessel. The sequence consisted of a hydroboration, azidation, and 1,3-dipolar cycloaddition and led to the regioselective formation of vinyl 1,2,3-triazoles in good yields.

Graphical abstract: A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Paper
Submitted
04 4月 2022
Accepted
17 5月 2022
First published
17 5月 2022

Org. Biomol. Chem., 2022,20, 6239-6244

A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

H. C. Zimba, L. L. Baldassari and A. V. Moro, Org. Biomol. Chem., 2022, 20, 6239 DOI: 10.1039/D2OB00635A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements