Issue 5, 2021

Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases

Abstract

The use of sensitive electrochemical sensors to detect biomarkers is an effective method for the early diagnosis of several neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, etc. However, the commercialization of enzyme/aptamer-based sensors is still hampered owing to the historic drawbacks of biorecognition elements including high cost, poor stability, and complex integration technology. Non-enzymatic electrochemical sensors are more attractive compared to their traditional counterparts and can be widely harnessed owing to their low cost, high stability, sensitivity, and ease of miniaturization. This review summarizes recent research progress focusing on the construction of non-enzymatic electrochemical sensors and analyzes their present use in the early diagnosis of NDs. Additionally, this review addresses the limitations and challenges of the use of current non-enzymatic electrochemical sensor technologies for the diagnosis of NDs and highlights the possible directions for future research.

Graphical abstract: Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases

Article information

Article type
Review Article
Submitted
24 11月 2020
Accepted
05 1月 2021
First published
05 1月 2021

J. Mater. Chem. B, 2021,9, 1175-1188

Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases

Z. Song, Y. Zhou, X. Han, J. Qin and X. Tang, J. Mater. Chem. B, 2021, 9, 1175 DOI: 10.1039/D0TB02745F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements