Issue 21, 2021

Magnetic nanocomplexes for gene delivery applications

Abstract

Gene delivery is an indispensable technique for various biomedical applications such as gene therapy, stem cell engineering and gene editing. Recently, magnetic nanoparticles (MNPs) have received increasing attention for their use in promoting gene delivery efficiency. Under magnetic attraction, gene delivery efficiency using viral or nonviral gene carriers could be universally enhanced. Besides, magnetic nanoparticles could be utilized in magnetic resonance imaging or magnetic hyperthermia therapy, providing extra theranostic opportunities. In this review, recent research integrating MNPs with a viral or nonviral gene vector is summarized from both technical and application perspectives. Applications of MNPs in cutting-edge research technologies, such as biomimetic cell membrane nano-gene carriers, exosome-based gene delivery, cell-based drug delivery systems or CRISPR/Cas9 gene editing, are also discussed.

Graphical abstract: Magnetic nanocomplexes for gene delivery applications

Article information

Article type
Review Article
Submitted
20 11月 2020
Accepted
25 3月 2021
First published
27 3月 2021

J. Mater. Chem. B, 2021,9, 4267-4286

Magnetic nanocomplexes for gene delivery applications

R. Huang, Z. Liu, W. Weng and C. Chang, J. Mater. Chem. B, 2021, 9, 4267 DOI: 10.1039/D0TB02713H

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