Themed collection Lab on a Chip Emerging Investigators

49 items
Critical Review

Periodontal disease and emerging point-of-care technologies for its diagnosis

Schematic representation of established biomarkers and various methods developed for diagnosing PD. Created with https://www.BioRender.com.

Graphical abstract: Periodontal disease and emerging point-of-care technologies for its diagnosis
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide

A simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.

Graphical abstract: Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing

Our work elucidates the importance of LNP formulation parameters, including microfluidic flow rate and organic excipient identity, for in vivo gene editing and presents an optimized delivery platform for the treatment of metabolic liver disease.

Graphical abstract: Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip

An “ex vivo trachea chip” integrates a tissue explant with a micromachined device, enables dynamic measurements of airway surface liquid volume, and reveals physiology of airway surface liquid secretion and absorption.

Graphical abstract: Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip
From the themed collection: Lab on a Chip Emerging Investigators
Paper

OMEF biochip for evaluating red blood cell deformability using dielectrophoresis as a diagnostic tool for type 2 diabetes mellitus

OMEF biochip is open-micro-electro-fluidic technology for stretching of single red blood cells (RBCs) based on dielectrophoresis and electrodeformation. The biochip assesses RBCs' deformability in type 2 diabetes mellitus as an effective diagnostic tool.

Graphical abstract: OMEF biochip for evaluating red blood cell deformability using dielectrophoresis as a diagnostic tool for type 2 diabetes mellitus
From the themed collection: Lab on a Chip Emerging Investigators
Paper

On the compatibility of single-cell microcarriers (nanovials) with microfluidic impedance cytometry

We investigate for the first time the compatibility of nanovials with microfluidic impedance cytometry, paving the way for the successful combination of these single-cell technologies.

Graphical abstract: On the compatibility of single-cell microcarriers (nanovials) with microfluidic impedance cytometry
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants

Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.

Graphical abstract: Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level

A new microfluidic platform – the AMF-SporeChip – enables immobilisation of arbuscular mycorrhizal fungal spores and confrontation of asymbiotic hyphae with physical obstacles, allowing the identification of various exploration strategies.

Graphical abstract: AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo

Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.

Graphical abstract: A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Enhanced acoustic streaming effects via sharp-edged 3D microstructures

The use of 3D sharp-edged microstructures enhances the versatility of sharp-edge driven microstreaming, with control over the magnitude and orientation of streaming vortexes for targeted particle microfluidic manipulation.

Graphical abstract: Enhanced acoustic streaming effects via sharp-edged 3D microstructures
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Quantitative mechanical stimulation of GPR68 using a novel 96 well flow plugin

Mechanosensitive proteins play a crucial role in a range of physiological processes, including hearing and regulating blood flow. This work presents a novel microfluidic approach compatible with 96-well plates to quantify their mechanosensitivity.

Graphical abstract: Quantitative mechanical stimulation of GPR68 using a novel 96 well flow plugin
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Cascaded elasto-inertial separation of malignant tumor cells from untreated malignant pleural and peritoneal effusions

A cascaded elasto-inertial cell separation device for pretreatment-free, high-recovery-ratio, and high-purity separation of malignant tumor cells from clinical malignant pleural and peritoneal effusions.

Graphical abstract: Cascaded elasto-inertial separation of malignant tumor cells from untreated malignant pleural and peritoneal effusions
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A hybrid fluorescent nanofiber membrane integrated with microfluidic chips towards lung-on-a-chip applications

Here, we report a fluorescent electrospun nanofiber membrane for integration with microfluidic chips towards lung-on-a-chip applications complemented with computational fluid dynamics modelling. Created with https://BioRender.com.

Graphical abstract: A hybrid fluorescent nanofiber membrane integrated with microfluidic chips towards lung-on-a-chip applications
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Micropillar enhanced FRET-CRISPR biosensor for nucleic acid detection

High-aspect ratio micropillar arrays are fabricated to enhance the detection performance of FRET-CRISPR assay.

Graphical abstract: Micropillar enhanced FRET-CRISPR biosensor for nucleic acid detection
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system

A droplet array SlipChip is presented to compartmentalize fluid into partitions at high density with a simple “Load-Slip” operation, and to perform digital LAMP quantification of SARS-CoV-2 nucleic acids with a random access system.

Graphical abstract: Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure

This organ-on-a-chip device of the outer blood retinal barrier will allow future studies of complex disease mechanisms and treatments of visual disorders using clinically relevant endpoints in vitro.

Graphical abstract: Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

μCB-seq: microfluidic cell barcoding and sequencing for high-resolution imaging and sequencing of single cells

We present a platform for on-chip molecular barcoding that combines high-resolution imaging with genomic analysis, enabling multi-modal phenotypic measurements in single cells.

Graphical abstract: μCB-seq: microfluidic cell barcoding and sequencing for high-resolution imaging and sequencing of single cells
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Double emulsion flow cytometry with high-throughput single droplet isolation and nucleic acid recovery

We have developed a novel workflow (sdDE-FACS, [s with combining low line]ingle [d with combining low line]roplet [D with combining low line]ouble [E with combining low line]mulsion FACS) that allows robust production, screening, and sorting of single double emulsion droplets with complete nucleic acid recovery.

Graphical abstract: Double emulsion flow cytometry with high-throughput single droplet isolation and nucleic acid recovery
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.

Graphical abstract: A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Deep learning guided image-based droplet sorting for on-demand selection and analysis of single cells and 3D cell cultures

To uncover the heterogeneity of cellular populations and multicellular constructs we show on-demand isolation of single mammalian cells and 3D cell cultures by coupling bright-field microdroplet imaging with real-time classification and sorting using convolutional neural networks.

Graphical abstract: Deep learning guided image-based droplet sorting for on-demand selection and analysis of single cells and 3D cell cultures
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Microfluidic impedance cytometry device with N-shaped electrodes for lateral position measurement of single cells/particles

In this paper, we present an N-shaped electrode-based microfluidic impedance cytometry for the measurement of the lateral position of single cells and particles in continuous flows.

Graphical abstract: Microfluidic impedance cytometry device with N-shaped electrodes for lateral position measurement of single cells/particles
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

Microfluidic rapid and autonomous analytical device (microRAAD) to detect HIV from whole blood samples

This handheld sample-to-answer platform combines blood cell separation, viral lysis, and isothermal nucleic acid amplification with capillary fluidics and heating controls to automatically detect HIV from blood samples within 90 minutes.

Graphical abstract: Microfluidic rapid and autonomous analytical device (microRAAD) to detect HIV from whole blood samples
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Magnetic microboats for floating, stiffness tunable, air–liquid interface epithelial cultures

Magnetically anchored microboats that can reliably and rapidly create air–liquid interface culture conditions in substrate-stiffness tunable epithelial cell cultures.

Graphical abstract: Magnetic microboats for floating, stiffness tunable, air–liquid interface epithelial cultures
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Automated “pick and transfer” of targeted cells using dielectrophoresis

A highly specific and automated device is desired for selective manipulation of single cells. The device in this work picks cells based on their inherent properties using dielectrophoresis and automatically transfers those at a transfer site.

Graphical abstract: Automated “pick and transfer” of targeted cells using dielectrophoresis
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips

Organ-on-chips made of blood: personalized medicine with microfluidics.

Graphical abstract: Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Measurement of the magnetic susceptibility of subtle paramagnetic solutions using the diamagnetic repulsion of polymer microparticles

The diamagnetic repulsion of polymer microspheres in a microfluidic platform enables the discrimination of magnetic susceptibility of subtle paramagnetic solutions.

Graphical abstract: Measurement of the magnetic susceptibility of subtle paramagnetic solutions using the diamagnetic repulsion of polymer microparticles
From the themed collection: Lab on a Chip Emerging Investigators
Paper

3D-printing enabled micro-assembly of a microfluidic electroporation system for 3D tissue engineering

The LEGO® concept is used to build 3D microchannel networks as a 3D μ-electrotransfection system for efficient exchange of nutrition and waste allowing 3D cell growth, while sustaining uniform 3D electric fields during cellular transfection.

Graphical abstract: 3D-printing enabled micro-assembly of a microfluidic electroporation system for 3D tissue engineering
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Integrated inertial-impedance cytometry for rapid label-free leukocyte isolation and profiling of neutrophil extracellular traps (NETs)

A novel integrated inertial-impedance cytometer for rapid and label-free electrical profiling of neutrophil extracellular trap formation (NETosis).

Graphical abstract: Integrated inertial-impedance cytometry for rapid label-free leukocyte isolation and profiling of neutrophil extracellular traps (NETs)
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain

Measuring neurotransmitters in the brain of living animals is a challenging task, especially when detailed information at high temporal resolution is required.

Graphical abstract: A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain
From the themed collection: Lab on a Chip Emerging Investigators
Paper

On-chip phenotypic investigation of combinatory antibiotic effects by generating orthogonal concentration gradients

We propose a microfluidic cell-based drug screening platform to investigate combinatory antibiotic effects by automatically generating concentration combinations.

Graphical abstract: On-chip phenotypic investigation of combinatory antibiotic effects by generating orthogonal concentration gradients
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism

Microfluidic diffusional sizing is combined with synchrotron radiation circular dichroism to resolve the secondary structure of protein mixtures.

Graphical abstract: Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Functional TCR T cell screening using single-cell droplet microfluidics

Droplet-based single cell platform allows functional screening and sorting of desirable TCR T cells to accelerate development of adoptive T cell therapies.

Graphical abstract: Functional TCR T cell screening using single-cell droplet microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

A biomimetic ‘adipose-tissue-on-chip’ integrated with nanoplasmonic biosensors for in situ multiplexed cytokine secretion analysis of obese adipose tissue.

Graphical abstract: An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Microfluidic diamagnetic water-in-water droplets: a biocompatible cell encapsulation and manipulation platform

We report a new technique that combines all aqueous droplet microfluidics with diamagnetic manipulation to isolate single-cell encapsulating water-in-water droplets.

Graphical abstract: Microfluidic diamagnetic water-in-water droplets: a biocompatible cell encapsulation and manipulation platform
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Measurement and mitigation of free convection in microfluidic gradient generators

Microfluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial variations in their local chemical environment.

Graphical abstract: Measurement and mitigation of free convection in microfluidic gradient generators
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A liver-immune coculture array for predicting systemic drug-induced skin sensitization

Recapitulation of liver-immune interactions in a microfluidic compartmentalized coculture array is sufficient to accurately predict systemic drug-induced skin sensitization.

Graphical abstract: A liver-immune coculture array for predicting systemic drug-induced skin sensitization
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis

Click-A+Chip identifies azido modified proteins with a novel graphene linker that performs copper-free-click chemistry on the chip's surface.

Graphical abstract: Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans

Aging produces a number of changes in the neuronal structure and function throughout a variety of organisms.

Graphical abstract: A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans
From the themed collection: Lab on a Chip Emerging Investigators
Paper

User-defined local stimulation of live tissue through a movable microfluidic port

A two-component, two-phase microfluidic device provides a movable port for user-selectable local stimulation of living tissue slices.

Graphical abstract: User-defined local stimulation of live tissue through a movable microfluidic port
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

A novel lung airway-on-a-chip system that uses a suspended hydrogel to enable epithelial–matrix–smooth muscle cell interactions.

Graphical abstract: Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model

Endothelial barrier function is known to be regulated by a number of molecular mechanisms; however, the role of biomechanical signals associated with blood flow is comparatively less explored.

Graphical abstract: Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Buffer-free integrative nanofluidic device for real-time continuous flow bioassays by ion concentration polarization

A novel portable device combining an aptamer probe and a nanofluidic component was developed, enabling the buffer-free continuous monitoring of small molecules in biological fluids.

Graphical abstract: Buffer-free integrative nanofluidic device for real-time continuous flow bioassays by ion concentration polarization
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Upgrading well plates using open microfluidic patterning

We developed an open microfluidic hydrogel-patterning technology that creates networks of cell culture chambers in well plates for multiculture experiments.

Graphical abstract: Upgrading well plates using open microfluidic patterning
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing

An automated microfluidic platform enables systematic high-throughput studies of mixing enhancement on the emission band-gap of in-flow synthesized perovskite quantum dots, resulting in kinetically tunable nanocrystals.

Graphical abstract: Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae

Movement response of zebrafish to chemicals is of interest in screening studies. We introduce a microfluidic device for partial immobilization, head L-arginine exposure and movement screening of zebrafish larvae under controlled conditions.

Graphical abstract: A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Probing blood cell mechanics of hematologic processes at the single micron level

Single-micron PDMS devices provide insight into the biophysical effects that vascular matrices have on platelets, RBCs, and neutrophils.

Graphical abstract: Probing blood cell mechanics of hematologic processes at the single micron level
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics

Light-based 3D printing of alginate hydrogels using ionic crosslinking enables reversible patterning with controlled degradation.

Graphical abstract: Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Image-based feedback and analysis system for digital microfluidics

A new feedback and biological analysis system for digital microfluidics that uses an imaging based setup.

Graphical abstract: Image-based feedback and analysis system for digital microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Lab on a Chip Emerging Investigators
49 items

About this collection

Lab on a Chip is please to present this growing web collection showcasing some of the best research in the field of miniaturisation being conducted by early career scientists. This series is edited by Dino Di Carlo (UCLA, USA), Yoon-Kyoung Cho (UNIST, South Korea) and Piotr Garstecki (IPC PAC, Poland), and aims to highlight up-and-coming researchers in the early stages of the independent careers.

This collection is updated when new Emerging Investigator series papers are published, so keep checking the page for new articles!

You can read our feature interviews with the corresponding authors included in the series on our blog. More details about the series and how to apply are available at rsc.li/loc-emerging

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