Polo-like kinase 4 (PLK4), a member of the serine/threonine protein kinase family, serves as a central regulator of centriole duplication and plays a critical role in eukaryotic mitosis.
A structurally novel and highly efficient PLK4 inhibitor was synthesized.
PLK4 is a serine/threonine protein kinase situated at the centrosome, acting as a crucial regulatory element in the regulation of cell mitosis and significantly contributing to the preservation of genomic integrity.
Based on scaffold hopping and computer-aid drug design, 38 pyrazolo[3,4-b]pyridine derivatives were synthesised. Among them, compound C03 showed acceptable activity with an IC50 value of 56 nM to TRKA kinase.
This review summarizes a novel perspective on emerging 1-D nanomaterials for cancer therapy and diagnosis, highlighting the unique shape-dependent properties, recent advancements, and unexplored nanomaterial types and therapeutic applications.