The synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs), by forming a C–C bond, can be achieved by cross-coupling reaction using transition metal catalysts.
An efficient and general photocatalytic three-component intermolecular alkylacylation of [1.1.1]propellane to synthezise 1,3-disubstituted BCP ketones has been achieved.
This study describes a green and novel multi-component reaction for direct perfluoroalkylation/heteroarylation of [1.1.1]propellane with heteroarenes and perfluoroalkyl iodines to diverse bicyclo[1.1.1]pentanes (BCPs).
This highlight reviews photochemical reactivity of diazo compounds as carbon-centred radical precursors. We unify key synthetic strategies and redefine their role beyond traditional carbene chemistry.
A three-component radical alkyl-acylation of [1.1.1]propellane to access a diverse array of 1,3-disubstituted BCP ketone derivatives.