Issue 13, 2019

Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

Abstract

The preparation of an easily available, air/moisture insensitive electrophilic reagent, trifluoromethyl-substituted selenium ylide 1a, and its reactions with a variety of nucleophiles including β-ketoesters and silyl enol ethers, aryl/heteroaryl boronic acids, electron-rich heteroarenes and sulfinates were described. These results suggest that reagent 1a is a broadly applicable electrophilic trifluoromethylating reagent.

Graphical abstract: Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

Supplementary files

Article information

Article type
Research Article
Submitted
16 十一月 2018
Accepted
03 一月 2019
First published
05 一月 2019

Org. Chem. Front., 2019,6, 2205-2209

Trifluoromethyl-substituted selenium ylide: a broadly applicable electrophilic trifluoromethylating reagent

H. Ge and Q. Shen, Org. Chem. Front., 2019, 6, 2205 DOI: 10.1039/C8QO01249K

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