Base-promoted synthesis of tetrasubstituted alkenylboronates from propargyl amines and B2pin2via dual 1,4-metallate shift and B–N elimination

Abstract

An efficient approach to synthesize tetrasubstituted alkenylboronates via a cascade borylation/B–N elimination of propargyl amines and B₂pin₂ is disclosed. A series of tetrasubstituted alkenylboronates were readily furnished using this strategy in good yields. In addition, a series of derivatizations of the tetrasubstituted alkenylboronates were also well achieved.