Issue 24, 2020

New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials

Abstract

This paper describes the intercalation of ciprofloxacin (CIP), a bactericidal antibiotic, into the interlayer space of layered double hydroxides (LDHs). To counter the problem of bacterial resistance and also to improve the properties of the CIP drug, the drug carrier approach promises significant benefits. Through the tight control over the synthesis parameters, particularly the amounts of CIP with respect to aluminum ions, two different LDH-CIP-intercalated structures were obtained with significantly different interlayer distances, namely, 21 and 32 Å. The samples were fully characterized in terms of composition, structure, and morphology. Interestingly, the structure with the largest interlayer distance incorporated both CIP anions and Al(CIP)3 complex, exhibiting the possibility to increase the CIP drug loading beyond the anionic-exchange capacity of the LDH carrier. In vitro release in a simulated intestinal fluid (phosphate-buffered solution at pH 7.5) confirmed that LDH was a potentially efficient carrier to deliver CIP in a sustained manner via the anion-exchange mechanism. Different release rates were observed depending on the intercalated structure, which were also influenced by the morphological characteristics.

Graphical abstract: New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials

Supplementary files

Article information

Article type
Paper
Submitted
03 一月 2020
Accepted
03 二月 2020
First published
07 二月 2020

New J. Chem., 2020,44, 10076-10086

New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials

N. F. Cherif, V. R. L. Constantino, O. Hamdaoui, F. Leroux and C. Taviot-Guého, New J. Chem., 2020, 44, 10076 DOI: 10.1039/D0NJ00045K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements