Issue 30, 2019

Antisolvent addition at extreme conditions

Abstract

This article describes the use of antisolvent addition at high-pressure to aid precipitation and recovery of high-pressure phases to ambient pressure. Paracetamol (PCM) was used as a model system to demonstrate the principle due to the extensive literature of paracetamol at high-pressure and ambient pressure. We have observed that we are able to recover the orthorhombic form of paracetamol to ambient pressure using this technique, although solvent-mediated transformations are a hurdle. During this investigation we observed a new methanol solvate of paracetamol that is similar in structure to the known form. The methanol solvate is stable to 0.2 GPa before transformation to the orthorhombic form that is known to be the stable form at high pressure.

Graphical abstract: Antisolvent addition at extreme conditions

Supplementary files

Article information

Article type
Paper
Submitted
12 三月 2019
Accepted
29 四月 2019
First published
29 四月 2019

CrystEngComm, 2019,21, 4437-4443

Antisolvent addition at extreme conditions

M. R. Ward and I. D. H. Oswald, CrystEngComm, 2019, 21, 4437 DOI: 10.1039/C9CE00365G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements