D. Hernández-Alonso, S. Zankowski, L. Adriaenssens and P. Ballester
Org. Biomol. Chem., 2015,13, 1022-1029
DOI:
10.1039/C4OB02108H,
Paper
We report the synthesis of a novel, water-soluble aryl-extended calix[4]pyrrole receptor. The water-solubilising groups are placed at the lower rim of the receptor, leaving the binding pocket unperturbed and open for modification. Binding studies were performed with a series of pyridine N-oxides. These studies revealed the ability of the receptor to bind neutral and charged N-oxides in basified water with stability constants higher than 104 M−1.