Issue 5, 2019

Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

Abstract

A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.

Graphical abstract: Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

Article information

Article type
Paper
Submitted
18 十二月 2018
Accepted
25 二月 2019
First published
26 二月 2019

React. Chem. Eng., 2019,4, 919-926

Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

Z. Fang, Y. Yang, J. Gu, Z. Yang, F. Dai, H. Zheng, W. He, C. Liu, N. Zhu and K. Guo, React. Chem. Eng., 2019, 4, 919 DOI: 10.1039/C8RE00335A

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