A Lactone-Enabled Approach to Metronidazole-Based Scaffolds

Xiaotan Yu, Gisela A. González-Montiel, Pradip Shit, Mayland Chang, Olaf Wiest and Shahriar Mobashery

J. Org. Chem., 2026
DOI: 10.1021/acs.joc.6c00559

Pharmacodynamic and Pharmacokinetic Limitations of Anti-protozoal drugs: A Comprehensive Review

Ashwini S. Patil and Manish S. Bhatia

Research Journal of Pharmacology and Pharmacodynamics, 2026, 18, 15
DOI: 10.52711/2321-5836.2026.00003

New KV7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising In Vivo Analgesic Effects

Frieda-Marie Bartz, Kinga Sałat, Katarzyna Urbańska, Jana Lemke, Pascal Rosendahl, Louis Schmidt, Lukas Schulig, Ulrike Garscha, Andreas Link and Patrick J. Bednarski

ACS Chem. Neurosci., 2025, 16, 2322
DOI: 10.1021/acschemneuro.5c00278

Crystallographic and Electroanalytical Analyses of Fexinidazole and Its Major Metabolites

Abdrrahman S. Surur, Siva S. M. Bandaru, Christian Fischer, Van T. D. Nguyen, Andreas Link, Patrick J. Bednarski and Carola Schulzke

ACS Omega, 2025, 10, 37985
DOI: 10.1021/acsomega.5c05115

Effects of CYP3A4 variants and drug–drug interactions on the metabolism of fexinidazole

Jinyu Hu, Haoxin Fu, Ruibin Li, Peiqi Wang, Jun Wu, Lu Cao, Chenjian Zhou and Ren-ai Xu

Biochemical Pharmacology, 2026, 247, 117730
DOI: 10.1016/j.bcp.2026.117730

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of Leishmania major Growth

Mahmoud El Hassab, Wagdy Eldehna, Zainab Elsayed, Mostafa Elbadawi, Ahmed Negmeldin, Marwa Balaha, Sherry Nasralla, Rehan Monir, Tamer Ibrahim, Manabu Abe, Haytham Tawfik, Adnan Bekhit and Loah Hemeda

DDDT, 2026, Volume 20, 1
DOI: 10.2147/DDDT.S570670