Issue 57, 2022

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Abstract

Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation.

Graphical abstract: Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Supplementary files

Article information

Article type
Communication
Submitted
30 4月 2022
Accepted
09 6月 2022
First published
21 6月 2022

Chem. Commun., 2022,58, 7912-7915

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

N. L. Fletcher, A. Prior, O. Choy, J. Humphries, P. Huda, S. Ghosh, Z. H. Houston, C. A. Bell and K. J. Thurecht, Chem. Commun., 2022, 58, 7912 DOI: 10.1039/D2CC02443H

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