Issue 9, 2021

Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

Abstract

The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry. In the last five decades, numerous innovative synthetic methodologies have been disclosed for these bis-oxacyclic fused heterocycles, expanding the scope of accessible building blocks, efficient and affordable catalysis, facile reaction conditions, and overall practicality of the process. In this comprehensive review article, we focus on showcasing the complete spectrum (from the first report in the 1970s to the latest disclosure in 2020) of efforts devoted towards the synthesis of diverse classes of furo-pyranones through systematization and critical analysis of the accumulated experimental knowledge and their elegant applications in total syntheses of biologically interesting related natural products.

Graphical abstract: Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

Article information

Article type
Review Article
Submitted
18 11月 2020
Accepted
23 1月 2021
First published
25 1月 2021

Org. Chem. Front., 2021,8, 2110-2162

Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

S. S. Thorat and R. Kontham, Org. Chem. Front., 2021, 8, 2110 DOI: 10.1039/D0QO01421D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements