Issue 6, 2021

Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

Abstract

Bacterial wound infections are a threat to public health. Although antibiotics currently provide front-line treatments for bacterial infections, the development of drug resistance coupled with the defenses provided through biofilm formation render these infections difficult, if not impossible, to cure. Antimicrobials from natural resources provide unique antimicrobial mechanisms and are generally recognized as safe and sustainable. Herein, an all-natural antimicrobial platform is reported. It is active against bacterial biofilms and accelerates healing of wound biofilm infections in vivo. This antimicrobial platform uses gelatin stabilized by photocrosslinking using riboflavin (vitamin B2) as a photocatalyst, and carvacrol (the primary constituent of oregano oil) as the active antimicrobial. The engineered nanoemulsions demonstrate broad-spectrum antimicrobial activity towards drug-resistant bacterial biofilms and significantly expedite wound healing in an in vivo murine wound biofilm model. The antimicrobial activity, wound healing promotion, and biosafety of these nanoemulsions provide a readily translatable and sustainable strategy for managing wound infections.

Graphical abstract: Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

Supplementary files

Article information

Article type
Communication
Submitted
11 11月 2020
Accepted
18 3月 2021
First published
18 3月 2021

Mater. Horiz., 2021,8, 1776-1782

Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

C. Li, R. F. Landis, J. M. Makabenta, A. Nabawy, T. Tronchet, D. Archambault, Y. Liu, R. Huang, M. Golan, W. Cui, J. Mager, A. Gupta, S. Schmidt-Malan, R. Patel and V. M. Rotello, Mater. Horiz., 2021, 8, 1776 DOI: 10.1039/D0MH01826K

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