An electrochemical SARS-CoV-2 biosensor inspired by glucose test strip manufacturing processes

Vincent J. Vezza; Adrian Butterworth; Perrine Lasserre; Ewen O. Blair; Alexander MacDonald; Stuart Hannah; Christopher Rinaldi; Paul A. Hoskisson; Andrew C. Ward; Alistair Longmuir; Steven Setford; Eoghan C. W. Farmer; Michael E. Murphy; Damion K. Corrigan

doi:10.1039/D1CC00936B

An electrochemical SARS-CoV-2 biosensor inspired by glucose test strip manufacturing processes†

Vincent J. Vezza,

*^a Adrian Butterworth,

^a Perrine Lasserre,

^a Ewen O. Blair,^a Alexander MacDonald,

^a Stuart Hannah,

^a Christopher Rinaldi,^b Paul A. Hoskisson,

^c Andrew C. Ward,

^d Alistair Longmuir,

^e Steven Setford,^e Eoghan C. W. Farmer,^f Michael E. Murphy^fg and Damion K. Corrigan

^a

Author affiliations

* Corresponding authors

^a Biomedical Engineering, University of Strathclyde, Glasgow, UK
E-mail: vincent.vezza@strath.ac.uk

^b Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK

^c Strathclyde Institute of Pharmacy and biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK

^d Civil & Environmental Engineering, University of Strathclyde, Glasgow, UK

^e LifeScan Scotland Ltd, Beechwood Park North, Inverness, UK

^f NHS GGC, Glasgow Royal Infirmary, Department of Microbiology, NEW Lister Building, Glasgow, UK

^g School of Medicine, Dentistry & Nursing, College of Medical Veterinary & Life Sciences, University of Glasgow, UK

Abstract

Accurate and rapid diagnostic tests are critical to reducing the impact of SARS-CoV-2. This study presents early, but promising measurements of SARS-CoV-2 using the ACE2 enzyme as the recognition element to achieve clinically relevant detection. The test provides a scalable route to sensitive, specific, rapid and low cost mass testing.

This article is part of the themed collections: ChemComm Milestones – First Independent Articles, Coronavirus articles - free to access collection and Chemical Communications HOT articles

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An electrochemical SARS-CoV-2 biosensor inspired by glucose test strip manufacturing processes†

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