Issue 11, 2019

Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy

Abstract

This study reports a strategy of combining a Pt(IV) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(IV) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum prodrug and folate groups are decorated on N-doped graphene quantum dots (N-GQDs). After cellular uptake of the nanoplatform, the platinum(IV) prodrug was reduced to an active anti-cancer Pt(II) species inside the cancerous cells, and simultaneously, near-infrared (NIR) light illumination induced the release of NO, accompanied by a prominent photothermal effect. This nanoplatform is capable of targeting intracellular co-delivery of Pt(II) and NO under 808 nm NIR light irradiation, accompanied by photothermal therapy, thereby leading to a significant synergistic therapeutic effect.

Graphical abstract: Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
18 10月 2018
Accepted
02 1月 2019
First published
03 1月 2019

J. Mater. Chem. B, 2019,7, 1867-1874

Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(IV) prodrug for enhanced anticancer therapy

S. Shi, Y. Li, Q. Zhang, S. Yang and J. Liu, J. Mater. Chem. B, 2019, 7, 1867 DOI: 10.1039/C8TB02743A

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