Issue 20, 2019

Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

Abstract

At present, increasing attention is being paid to photothermal therapy corresponding to the second near infrared (NIR-II) range (1000–1700 nanometers); however, its biomedical applications related to carbon-based nanomaterials (CNMs) have always been limited by the large-scale fabrication of excellent diagnostic probes with a suitable size and optical absorption cross-section. Herein, we successfully prepared Bi@C nanoparticles with a suitable size and high output (3.14 g per patch) through a one-pot hydrothermal method. By combining Bi with carbon, the optical absorption in the NIR-II range was enhanced compared to that for single carbon; moreover, Bi@C could no longer be easily oxidized due to the protection of outer C compared with individual Bi. Furthermore, because of the high atomic number of Bi (Z = 83), the Bi@C nanoparticles exhibited computed imaging contrast properties. According to the in vitro and in vivo experiments, the Bi@C nanoparticles could ablate cancer cells under illumination with a 1064 nm laser with deeper penetration and an appropriate permissible exposure (MPE) to the laser (1 W cm−2), showing excellent performance for the diagnosis and treatment of tumors. This study provides a simple method to synthesize metal–carbon nanocomposites to enhance the NIR-II optical absorption efficiency for effective deep-seated tumor photothermal therapy and will further broaden the applications of CNMs.

Graphical abstract: Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

  • This article is part of the themed collection: Nanocarbons

Supplementary files

Article information

Article type
Paper
Submitted
20 2月 2019
Accepted
30 4月 2019
First published
01 5月 2019

Nanoscale, 2019,11, 9906-9911

Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

W. Zhen, S. An, W. Wang, Y. Liu, X. Jia, C. Wang, M. Zhang and X. Jiang, Nanoscale, 2019, 11, 9906 DOI: 10.1039/C9NR01557D

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