Issue 43, 2022

Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

Abstract

A series of 2,2′-bipyridine derivatives appended with structurally unique biomolecular auxiliaries were synthesized and investigated for their ability to ameliorate multifaceted amyloid toxicity. Our results highlight the roles of the metal-chelating bipyridine core and functional auxiliaries in effectively modulating metal-independent and -dependent amyloid toxicity, and oxidative stress observed in Alzheimer's disease (AD).

Graphical abstract: Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

Supplementary files

Article information

Article type
Communication
Submitted
25 2月 2022
Accepted
25 4月 2022
First published
25 4月 2022

Chem. Commun., 2022,58, 6288-6291

Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

D. Padhi, C. Balachandra, M. Ramesh and T. Govindaraju, Chem. Commun., 2022, 58, 6288 DOI: 10.1039/D2CC01168A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements