Issue 6, 2022

Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization

Abstract

Matrices formed by self-assembly of amino acids and their derivatives are suitable for cell spreading, migration and proliferation, and widely used in tissue engineering and organ regeneration, due to the biological endogenous molecules and weak intermolecular forces. The self-assembly process is not only affected by dynamic and thermodynamic factors, but also the assembled space. In this work, capillary tubes with different diameters are chosen to mimic a confined environment and the effect of capillary space on the self-assembly behavior of Fmoc-amino acids with different oil–water partition coefficients (log P) was investigated. The amino acids can form special morphologies and structures through the limitation of the Brownian motion and the template effect exerted by a confined environment. Meanwhile, the obtained parallel ordered fiber network was applied to mimic the extracellular matrix (ECM) and support the adhesion and proliferation of monolayer flat epithelial cells (HUVECs). We believe that the exploration of the self-assembly of amino acids in confined space can promote the understanding of the supramolecular self-assembly mechanism and offer a great opportunity in building the specific structures of vessels or tissues in vitro.

Graphical abstract: Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization

Supplementary files

Article information

Article type
Paper
Submitted
10 1月 2022
Accepted
26 1月 2022
First published
28 1月 2022

Biomater. Sci., 2022,10, 1470-1475

Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization

Q. Dong, M. Wang, A. Wang, C. Yu, S. Bai, J. Yin and Q. You, Biomater. Sci., 2022, 10, 1470 DOI: 10.1039/D2BM00041E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements