Issue 2, 2024

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Abstract

Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide. Several approaches are currently employed as cancer treatment options. Among them, mitochondrial targeting offers a highly promising approach to precise cancer treatment. Indeed, various engineered nanomaterials loaded with chemotherapeutic drugs were developed to precisely target mitochondria. This review investigates the challenges of cancer treatment, particularly in photodynamic, photothermal, and chemotherapies. Drawing on insights from mitochondrial biology and targeting materials, it unravels the complex connection between cancer, mitochondria, and nanoplatform-based targeted therapy. The attention is specifically on nanoparticles and their emerging role in precisely targeting mitochondria, offering solutions for effective treatment of cancer.

Graphical abstract: Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Article information

Article type
Review Article
Submitted
31 8月 2023
Accepted
18 11月 2023
First published
21 12月 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 409-431

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

S. R. Pandya, H. Singh, M. F. Desimone, J. Singh, N. George and S. Jasani, Mater. Adv., 2024, 5, 409 DOI: 10.1039/D3MA00629H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements