Issue 31, 2023

Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

Abstract

Hydride transfer (HT) is a fundamental step in a wide range of reaction pathways, including those mediated by dihydropyridinates (DHPs). Coordination of ions directly to the pyridine ring or functional groups stemming therefrom, provides a powerful approach for influencing the electronic structure and in turn HT chemistry. Much of the work in this area is inspired by the chemistry of bioinorganic systems including NADH. Coordination of metal ions to pyridines lowers the electron density in the pyridine ring and lowers the reduction potential: lower-energy reactions and enhanced selectivity are two outcomes from these modifications. Herein, we discuss approaches for the preparation of DHP–metal complexes and selected examples of their reactivity. We suggest further areas in which these metallated DHPs could be developed and applied in synthesis and catalysis.

Graphical abstract: Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

Article information

Article type
Perspective
Submitted
22 4月 2023
Accepted
14 7月 2023
First published
17 7月 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 8234-8248

Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

L. W. T. Parsons and L. A. Berben, Chem. Sci., 2023, 14, 8234 DOI: 10.1039/D3SC02080K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements