Issue 44, 2023

Ultra-selective 1D clean in-phase correlation spectroscopy

Abstract

Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.

Graphical abstract: Ultra-selective 1D clean in-phase correlation spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
17 3月 2023
Accepted
19 4月 2023
First published
20 4月 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 6734-6737

Ultra-selective 1D clean in-phase correlation spectroscopy

D. A. Taylor, P. Kiraly, P. Bowyer, M. Nilsson, L. Castañar, G. A. Morris and R. W. Adams, Chem. Commun., 2023, 59, 6734 DOI: 10.1039/D3CC01333B

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