Issue 4, 2022

Bio-click chemistry: a bridge between biocatalysis and click chemistry

Abstract

The fields of click chemistry and biocatalysis have rapidly grown over the last two decades. The development of robust and active biocatalysts and the widespread use of straightforward click reactions led to significant interactions between these two fields. Therefore the name bio-click chemistry seems to be an accurate definition of chemoenzymatic reactions cooperating with click transformations. Bio-click chemistry can be understood as the approach towards molecules of high-value using a green and sustainable approach by exploiting the potential of biocatalytic enzyme activity combined with the reliable nature of click reactions. This review summarizes the principal bio-click chemistry reactions reported over the last two decades, with a special emphasis on small molecules. Contributions to the field of bio-click chemistry are manifold, but the synthesis of chiral molecules with applications in medicinal chemistry and sustainable syntheses will be especially highlighted.

Graphical abstract: Bio-click chemistry: a bridge between biocatalysis and click chemistry

Article information

Article type
Review Article
Submitted
02 11月 2021
Accepted
28 12月 2021
First published
12 1月 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 1932-1949

Bio-click chemistry: a bridge between biocatalysis and click chemistry

D. F. Rodríguez, Y. Moglie, C. A. Ramírez-Sarmiento, S. K. Singh, K. Dua and F. C. Zacconi, RSC Adv., 2022, 12, 1932 DOI: 10.1039/D1RA08053A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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