Issue 17, 2022

Recent advances in redox-responsive nanoparticles for combined cancer therapy

Abstract

The combination of multiple therapeutic modalities has attracted increasing attention as it can achieve better therapeutic effects through different treatment mechanisms. However, traditional small molecule agents are non-specific to the tumor tissue, which leads to off-target toxic effects for healthy tissues. To solve this problem, a number of stimuli-responsive nanoscale drug-delivery systems have been developed. Among these stimuli, a high concentration of reactive oxygen species (ROS) and glutathione (GSH) are characteristic of the tumor microenvironment (TME), which can distinguish it from normal tissue. In this review, we summarize the redox-responsive nanoparticles (NPs) reported in the past three years classified by different functional groups, including GSH-responsive disulfide, ditelluride, and multivalent metal ions, ROS-responsive thioketal, arylboronic ester, aminoacrylate, and bilirubin as well as GSH/ROS dual-responsive diselenide and dicarbonyl thioethers. The prospects and challenges of redox-responsive NPs are also discussed.

Graphical abstract: Recent advances in redox-responsive nanoparticles for combined cancer therapy

Article information

Article type
Minireview
Submitted
08 4月 2022
Accepted
20 7月 2022
First published
28 7月 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 3504-3516

Recent advances in redox-responsive nanoparticles for combined cancer therapy

Y. Yang and W. Sun, Nanoscale Adv., 2022, 4, 3504 DOI: 10.1039/D2NA00222A

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