Issue 49, 2022

Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

Abstract

The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle).

Graphical abstract: Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

Supplementary files

Article information

Article type
Communication
Submitted
13 4月 2022
Accepted
20 5月 2022
First published
20 5月 2022

Chem. Commun., 2022,58, 6890-6893

Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

C. C. Hanna, J. W. C. Maxwell, H. S. Ismanto, A. S. Ashhurst, L. M. Artner, S. Rudrawar, W. J. Britton, S. Yamasaki and R. J. Payne, Chem. Commun., 2022, 58, 6890 DOI: 10.1039/D2CC02100E

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