Issue 50, 2022

Triazine-pyridine chemistry for protein labelling on tyrosine

Abstract

Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells.

Graphical abstract: Triazine-pyridine chemistry for protein labelling on tyrosine

Supplementary files

Article information

Article type
Communication
Submitted
17 3月 2022
Accepted
23 5月 2022
First published
24 5月 2022

Chem. Commun., 2022,58, 7066-7069

Triazine-pyridine chemistry for protein labelling on tyrosine

H. Jiang, Q. Zhang, Y. Zhang, H. Feng, H. Jiang, F. Pu, R. Yu, Z. Zhong, C. Wang, Y. M. E. Fung, P. Blasco, Y. Li, T. Jiang and X. Li, Chem. Commun., 2022, 58, 7066 DOI: 10.1039/D2CC01528E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements