Issue 15, 2021

Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation

Abstract

Cytotoxic anticancer drugs used in chemotherapy are often antiproliferative agents that preferentially kill rapidly growing cancer cells. Their mechanism relies mainly on the enhanced proliferation rate of cancer cells and is not genuinely selective for cancer cells. Therefore, these drugs can also significantly affect healthy cells. Prodrug therapy provides an alternative approach using a less cytotoxic form of anticancer drug. It involves the synthesis of inactive drug derivatives which are converted to an active form inside the body and, preferably, only at the site of cancerous tissues, thereby reducing adverse drug reaction (ADR) events. Herein, we demonstrate a prodrug activation strategy by utilizing the reaction between aryl azide and endogenous acrolein. Since acrolein is generally overproduced by most cancer cells, we anticipate our strategy as a starting point for further applications in mouse models with various cancers. Furthermore, cancer drugs that have had therapeutic index challenges might be reconsidered for application by utilizing our strategy.

Graphical abstract: Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation

Supplementary files

Article information

Article type
Edge Article
Submitted
04 11月 2020
Accepted
16 3月 2021
First published
01 4月 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 5438-5449

Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation

A. R. Pradipta, P. Ahmadi, K. Terashima, K. Muguruma, M. Fujii, T. Ichino, S. Maeda and K. Tanaka, Chem. Sci., 2021, 12, 5438 DOI: 10.1039/D0SC06083F

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