Issue 34, 2021

Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Abstract

Polypeptoids are peptidomimetic polymers, and their origin can be traced back to the early 1990s. The facile synthesis of sequence-controlled and sequence-defined polypeptoids still faces many challenges. Very recently, the Ugi reaction has been introduced into polypeptoid chemistry. In this mini review, the recent progress in the application of the Ugi reaction for the synthesis of sequence-controlled polypeptoids is summarized. The influence of the sequence structure on polypeptoid properties is presented. Moreover, the future development of the Ugi reaction for the synthesis of sequence-controlled and sequence-defined polypeptoids is discussed.

Graphical abstract: Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Article information

Article type
Minireview
Submitted
15 5月 2021
Accepted
18 7月 2021
First published
19 7月 2021

Polym. Chem., 2021,12, 4895-4902

Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Y. Zhu and Y. Tao, Polym. Chem., 2021, 12, 4895 DOI: 10.1039/D1PY00658D

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