Issue 16, 2021

Chiral 3D DNA origami structures for ordered heterologous arrays

Abstract

The DNA origami technique allows the facile design and production of three-dimensional shapes from single template strands of DNA. These can act as functional devices with multiple potential applications but are constrained by practical limitations on size. Multi-functionality could be achieved by connecting together distinct DNA origami modules in an ordered manner. Arraying of non-identical, three-dimensional DNA origamis in an ordered manner is challenging due for example, to a lack of compatible rotational symmetries. Here we show that we can design and build ordered DNA structures using non-identical 3D building blocks by using DNA origami snub-cubes in left-handed and right-handed forms. These can be modified such that one form only binds to the opposite-handed form allowing regular arrays wherein building blocks demonstrate alternating chirality.

Graphical abstract: Chiral 3D DNA origami structures for ordered heterologous arrays

Supplementary files

Article information

Article type
Paper
Submitted
24 5月 2021
Accepted
04 7月 2021
First published
05 7月 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 4685-4691

Chiral 3D DNA origami structures for ordered heterologous arrays

Md. S. Islam, G. D. Wilkens, K. Wolski, S. Zapotoczny and J. G. Heddle, Nanoscale Adv., 2021, 3, 4685 DOI: 10.1039/D1NA00385B

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